Manchester United will be looking to cement their position at the top of Group L when they make the Europa League trip to AZ Alkmaar.Thursday's meeting will be the first between these two sides and although 20-time English champions United won their opener 1-0 at home to Astana, they are expected to find life difficult at the AFAS Stadion.
Ole Gunnar Solskjaer's men have only won two of their last 12 league games and are struggling massively away from home, having failed to win any of their last nine competitive matches in all competitions.
United drew 1-1 at home to Arsenal on Monday evening, a result which marked the Red Devils' worst start to a PL campaign, and a changed line-up is expected for the trip to Holland.
France international Paul Pogba has been left out of the squad due to a recurring foot problem, while Anthony Martial, Phil Jones, Aaron Wan-Bissaka and Luke Shaw have all stayed at home.
Left-back Brandon Williams, who is one of 10 Academy graduates in the squad, could make his first European appearance, while 17-year-old forward Mason Greenwood is tipped to start up front.
AZ head into the clash full of confidence, having suffered just one defeat from 14 matches in all competitions, and they will be aiming to extend their unbeaten run at home to seven games.
The Dutch outfit will be without midfielder Dani de Wit, who is still recovering from a broken nose, while defender Jonas Svensson is suspended after he received a straight red card during the 2-2 draw against Partizan Belgrade in their Group L opener.