The 27-year-old joined permanently over the summer from Porto, having spent last season on-loan at Molineux, and he has started all 22 Premier League games this term.
But the centre-back was shown a red card in the loss to Manchester City last time out and will start a three-game ban this weekend.
The versatile Leander Dendoncker is likely to drop back from midfield to deputise in his absence, while Romain Saiss should be drafted into the centre of the park.
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44'
Wolverhampton v Leicester City
bet365 match odds: Wolves 11/8, Draw 11/5, Leicester 12/5
The 27-year-old joined permanently over the summer from Porto, having spent last season on-loan at Molineux, and he has started all 22 Premier League games this term.
But the centre-back was shown a red card in the loss to Manchester City last time out and will start a three-game ban this weekend.
The versatile Leander Dendoncker is likely to drop back from midfield to deputise in his absence, while Romain Saiss should be drafted into the centre of the park.
Head to Head Comparison
Wolverhampton Wanderers - Last 5 Matches
Leicester City - Last 5 Matches