The Saints' top scorer has fully recovered from a hamstring injury, which has seen him miss the last three matches in all competitions, and he has been back in training this week.
Ings has an impressive record against Everton - scoring at Goodison Park in both the league and the EFL Cup this season - and also bagged against the Blues as a Liverpool player.
After playing 120 minutes in their FA Cup tie with Derby in midweek, Ralph Hasenhuttl is expected to make several changes, with Pierre-Emile Hojbjerg, Charlie Austin and Yan Valery all available after suspension.
Michael Obafemi remains sidelined by a hamstring problem while the Saints boss will make a late decision on the fitness of Ryan Bertrand, Shane Long and Mario Lemina.
Everton head to the south coast after returning to winning ways against Bournemouth last week although their away form will be a concern for Marco Silva, with the Toffees winning just one of their last six on the road.
Ademola Lookman is expected to start at St Mary's after an impressive display last week while Silva insists he is happy to continue with Richarlison playing as a striker. One man who looks set to miss out for the visitors is Phil Jagielka, who suffered an injury in training this week.
Everton have lost on their last two visits to St Mary's, including a 4-1 defeat to Saints in this fixture last season when Charlie Austin hit a second-half brace.
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Southampton v Everton
bet365 match odds: Southampton 7/4, Draw 12/5, Everton 17/10
The Saints' top scorer has fully recovered from a hamstring injury, which has seen him miss the last three matches in all competitions, and he has been back in training this week.
Ings has an impressive record against Everton - scoring at Goodison Park in both the league and the EFL Cup this season - and also bagged against the Blues as a Liverpool player.
After playing 120 minutes in their FA Cup tie with Derby in midweek, Ralph Hasenhuttl is expected to make several changes, with Pierre-Emile Hojbjerg, Charlie Austin and Yan Valery all available after suspension.
Michael Obafemi remains sidelined by a hamstring problem while the Saints boss will make a late decision on the fitness of Ryan Bertrand, Shane Long and Mario Lemina.
Everton head to the south coast after returning to winning ways against Bournemouth last week although their away form will be a concern for Marco Silva, with the Toffees winning just one of their last six on the road.
Ademola Lookman is expected to start at St Mary's after an impressive display last week while Silva insists he is happy to continue with Richarlison playing as a striker. One man who looks set to miss out for the visitors is Phil Jagielka, who suffered an injury in training this week.
Everton have lost on their last two visits to St Mary's, including a 4-1 defeat to Saints in this fixture last season when Charlie Austin hit a second-half brace.
Head to Head Comparison
Southampton - Last 5 Matches
Everton - Last 5 Matches