Sheffield United are the latest team trying to end Liverpool's 100% league record when the teams meet in Saturday's early kick-off.The Blades have moved into the top half of the table following last week's win at Liverpool's Merseyside rivals Everton, with Chris Wilder's men looking to record back-to-back Premier League wins for the first time in 13 years.
The hosts made 10 changes in their midweek League Cup defeat to Sunderland, with Wilder expected to revert to a more familiar starting XI.
Billy Sharp completes the final game of his three-match ban following his sending off against Southampton, while David McGoldrick faces a late fitness on a groin problem.
Liverpool head to South Yorkshire looking to make it seven wins out of seven in the Premier League and are boosted by the news that Sadio Mane is available despite picking up a dead leg in their EFL Cup success at MK Dons.
Divock Origi will return to the squad after recovering from the ankle injury suffered in the recent win over Newcastle, but the Reds will be without the injured Xherdan Shaqiri, who is out with a calf issue.
Liverpool have never won a game at Bramall Lane in the Premier League era, drawing twice and losing once in their three visits. However, Jurgen Klopp's men have won their last 12 Premier League matches against promoted sides.