The Magpies are without a win in five games in the Premier League and they desperately need to take all three points away from the meeting with fellow relegation candidates Cardiff.
They have won their last two home fixtures with the Bluebirds, although one of those came in the Championship, and the pair played out a goalless draw in Wales earlier this term.
Newcastle edged past Blackburn in the FA Cup on Tuesday but that victory came at a price with Clark and Lascelles both limping out of the match.
Fabian Schar and Isaac Hayden also sustained injuries in the third-round replay but should be available for Rafael Benitez.
Cardiff remain in contention to defy the odds and secure a second successive season in the Premier League and they head into the game sitting just above the bottom three.
Neil Warnock has added Everton forward Oumar Niasse to his squad on-loan until the end of the season and he could go straight into the starting XI.
Captain Sean Morrison is expected to miss out with the club confirming he had undergone “a procedure” earlier this week.
A loss for Newcastle would equal the club’s worst record after 23 top-flight matches, set in 1966-67 and 1988-89.
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Newcastle United v Cardiff City
bet365 match odds: Newcastle 19/20, Draw 12/5, Cardiff 7/2
The Magpies are without a win in five games in the Premier League and they desperately need to take all three points away from the meeting with fellow relegation candidates Cardiff.
They have won their last two home fixtures with the Bluebirds, although one of those came in the Championship, and the pair played out a goalless draw in Wales earlier this term.
Newcastle edged past Blackburn in the FA Cup on Tuesday but that victory came at a price with Clark and Lascelles both limping out of the match.
Fabian Schar and Isaac Hayden also sustained injuries in the third-round replay but should be available for Rafael Benitez.
Cardiff remain in contention to defy the odds and secure a second successive season in the Premier League and they head into the game sitting just above the bottom three.
Neil Warnock has added Everton forward Oumar Niasse to his squad on-loan until the end of the season and he could go straight into the starting XI.
Captain Sean Morrison is expected to miss out with the club confirming he had undergone “a procedure” earlier this week.
A loss for Newcastle would equal the club’s worst record after 23 top-flight matches, set in 1966-67 and 1988-89.
Newcastle United - Last 5 Matches
Cardiff City - Last 5 Matches