Having been forced to make changes for last week's team that won at Brighton, Klopp now has more problems at the back with Trent Alexander-Arnold the latest injury concern.
The England defender suffered an injury prior to the win at the Amex Stadium but managed to get through 90 minutes, but the Reds are having to keep a day-to-day check on his fitness.
Liverpool are also set to hand a late fitness test to Georginio Wijnaldum while Adam Lallana could feature after returning to training, but Dejan Lovren and Joe Gomez are still sidelined.
The Reds are going in search of a seventh consecutive Premier League home victory, while Klopp's men have kept 12 clean sheets in their last 16 Premier League home games.
Meanwhile, Roy Hodgson confirmed in Friday's pre-match press conference that veteran Julian Speroni will start in goal at Anfield, with Vicente Guaita and Wayne Hennessey both sidelined by injuries.
Pape Souare is out with a dislocated shoulder, but Christian Benteke is in contention to face his former club having come off the bench in the defeat to Watford last weekend.
The head-to-head stats favour Liverpool, who have won their last four meetings with the Eagles - including a 2-0 win at Selhurst Park in August. Palace though were the last team to win at Anfield in the Premier League - with a 2-1 success back in April 2017.
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Liverpool v Crystal Palace
bet365 match odds: Liverpool 2/11, Draw 7/1, Crystal Palace 16/1
Having been forced to make changes for last week's team that won at Brighton, Klopp now has more problems at the back with Trent Alexander-Arnold the latest injury concern.
The England defender suffered an injury prior to the win at the Amex Stadium but managed to get through 90 minutes, but the Reds are having to keep a day-to-day check on his fitness.
Liverpool are also set to hand a late fitness test to Georginio Wijnaldum while Adam Lallana could feature after returning to training, but Dejan Lovren and Joe Gomez are still sidelined.
The Reds are going in search of a seventh consecutive Premier League home victory, while Klopp's men have kept 12 clean sheets in their last 16 Premier League home games.
Meanwhile, Roy Hodgson confirmed in Friday's pre-match press conference that veteran Julian Speroni will start in goal at Anfield, with Vicente Guaita and Wayne Hennessey both sidelined by injuries.
Pape Souare is out with a dislocated shoulder, but Christian Benteke is in contention to face his former club having come off the bench in the defeat to Watford last weekend.
The head-to-head stats favour Liverpool, who have won their last four meetings with the Eagles - including a 2-0 win at Selhurst Park in August. Palace though were the last team to win at Anfield in the Premier League - with a 2-1 success back in April 2017.
Head to Head Comparison
Liverpool - Last 5 Matches
Crystal Palace - Last 5 Matches