A win for Sheffield United at Goodison Park will take them above Everton in the table, while the hosts are eyeing a top-half spot.There are just two points separating the two sides going into Saturday's clash, with both teams looking to bounce back from league defeats - against Southampton and Bournemouth respectively - last weekend.
Everton are unbeaten in their last four Premier League meetings with the Blades and go in search of three wins out of three in home league fixtures this season, following victories over Watford and Wolves.
Marco Silva will again be without midfielder Andre Gomes, who is sidelined with a rib injury that kept him out of the clash at the Vitality Stadium last week. Jean-Philippe Gbamin also remains on the sidelines, with a thigh problem.
As for the visitors, they will be missing striker Billy Sharp, following his sending off against the Saints last Saturday, while Mo Besic - on loan from the Toffees - is ineligible to face his parent club.
One major plus for Chris Wilder is the return to full fitness of Callum Robinson following a hamstring injury, and he was on the bench last week.
Sheffield United have picked up useful draws in their first two away games, but they are still winless in their last 12 top-flight away matches, which stretches back to December 2006.