The Hatters have decided not to appeal Hylton's red card in the 1-1 draw with Sunderland on Saturday so he will begin a four-match suspension.
Harry Cornick is unlikely to be fit with an ankle problem so Elliot Lee could be pushed into a more forward role as the League One side aim to set up a fourth-round visit to Chelsea.
Interim manager Mick Harford, who took temporary charge following Nathan Jones' move to Stoke, has ruled himself out of the job on a permanent role.
Sheffield Wednesday midfielder Sam Hutchinson is rated at 50/50 after sustaining a knock in the 3-0 loss at Hull.
Fellow midfielder Joey Pelupessy is also a doubt with an ankle injury and will be assessed ahead of the trip to Kenilworth Road.
The Owls are also worrying over goalkeeper Kieren Westwood's toe injury.
The experienced stopper has gone for a scan on the problem, with Cameron Dawson ready to deputise.
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Luton Town v Sheffield Wednesday
bet365 match odds: Luton 7/5, Draw 12/5, Sheffield Wednesday 11/5
The Hatters have decided not to appeal Hylton's red card in the 1-1 draw with Sunderland on Saturday so he will begin a four-match suspension.
Harry Cornick is unlikely to be fit with an ankle problem so Elliot Lee could be pushed into a more forward role as the League One side aim to set up a fourth-round visit to Chelsea.
Interim manager Mick Harford, who took temporary charge following Nathan Jones' move to Stoke, has ruled himself out of the job on a permanent role.
Sheffield Wednesday midfielder Sam Hutchinson is rated at 50/50 after sustaining a knock in the 3-0 loss at Hull.
Fellow midfielder Joey Pelupessy is also a doubt with an ankle injury and will be assessed ahead of the trip to Kenilworth Road.
The Owls are also worrying over goalkeeper Kieren Westwood's toe injury.
The experienced stopper has gone for a scan on the problem, with Cameron Dawson ready to deputise.
Head to Head Comparison
Luton Town - Last 5 Matches
Sheffield Wednesday - Last 5 Matches