Defender Edwards missed the 0-0 draw at Millwall last Saturday due to a hip problem.
The match could see final Stoke appearances for veteran midfielders Charlie Adam and Darren Fletcher.
The Potters on Wednesday announced that the pair, plus goalkeeper Jakob Haugaard, will be leaving the club this summer when their contracts expire.
Second-placed Sheffield United, who were promoted to the Premier League last weekend, look to have a full squad available for the game.
It appeared no injuries were sustained during the 2-0 win at Ipswich on Saturday, which saw Billy Sharp make his comeback having recovered from a hamstring issue.
That result all but sealed the Blades' promotion, and it was confirmed the following day after Leeds drew 1-1 with Aston Villa.
Chris Wilder's men have a chance of claiming the title on Sunday, lying three points behind leaders Norwich - who finish their season at Villa - and with a goal difference that is superior to the Canaries' by two.
*odds correct at time of posting and are subject to change
Stoke v Sheffield United
Paddy Power pre-match odds: Stoke 23/10, Draw 23/10, Sheffield United*
Defender Edwards missed the 0-0 draw at Millwall last Saturday due to a hip problem.
The match could see final Stoke appearances for veteran midfielders Charlie Adam and Darren Fletcher.
The Potters on Wednesday announced that the pair, plus goalkeeper Jakob Haugaard, will be leaving the club this summer when their contracts expire.
Second-placed Sheffield United, who were promoted to the Premier League last weekend, look to have a full squad available for the game.
It appeared no injuries were sustained during the 2-0 win at Ipswich on Saturday, which saw Billy Sharp make his comeback having recovered from a hamstring issue.
That result all but sealed the Blades' promotion, and it was confirmed the following day after Leeds drew 1-1 with Aston Villa.
Chris Wilder's men have a chance of claiming the title on Sunday, lying three points behind leaders Norwich - who finish their season at Villa - and with a goal difference that is superior to the Canaries' by two.
*odds correct at time of posting and are subject to change
Head to Head Comparison
Stoke City - Last 5 Matches
Sheffield United - Last 5 Matches