Iorfa starts a three-game ban following his straight red card in last week's draw at Preston, but fellow defender Achraf Lazaar could return after illness.
Boss Steve Bruce must decide whether to recall goalkeeper Keiren Westwood, fit again after a knee injury, or retain Cameron Dawson, while third-choiceJoe Wildsmith is also in contention for the final game of the season.
Midfielder Sam Hutchinson (hamstring) and Rolando Aarons (ankle) will be assessed.
QPR caretaker boss John Eustace must decide whether to recall player of the year Luke Freeman and several other senior players.
Freeman was an unused substitute in last week's home defeat to Nottingham Forest as Eustace uses the run-in to take a good look at his squad. Strikers Matt Smith and Nahki Wells are also pushing for recalls.
Central defender Joel Lynch remains doubtful due to a hamstring injury which has has kept him out of the last two matches.
Midfielder Jordan Cousins (ankle) is out, while defenders Jake Bidwell (thigh), Grant Hall (groin) and Angel Rangel (calf) will be assessed.
*odds correct at time of posting and are subject to change
88'
Sheffield Wednesday v QPR
Paddy Power pre-match odds: Sheffield Wednesday 4/6, Draw 5/2, QPR 7/2*
Iorfa starts a three-game ban following his straight red card in last week's draw at Preston, but fellow defender Achraf Lazaar could return after illness.
Boss Steve Bruce must decide whether to recall goalkeeper Keiren Westwood, fit again after a knee injury, or retain Cameron Dawson, while third-choiceJoe Wildsmith is also in contention for the final game of the season.
Midfielder Sam Hutchinson (hamstring) and Rolando Aarons (ankle) will be assessed.
QPR caretaker boss John Eustace must decide whether to recall player of the year Luke Freeman and several other senior players.
Freeman was an unused substitute in last week's home defeat to Nottingham Forest as Eustace uses the run-in to take a good look at his squad. Strikers Matt Smith and Nahki Wells are also pushing for recalls.
Central defender Joel Lynch remains doubtful due to a hamstring injury which has has kept him out of the last two matches.
Midfielder Jordan Cousins (ankle) is out, while defenders Jake Bidwell (thigh), Grant Hall (groin) and Angel Rangel (calf) will be assessed.
*odds correct at time of posting and are subject to change
Head to Head Comparison
Sheffield Wednesday - Last 5 Matches
Queens Park Rangers - Last 5 Matches