Lutons efforts to bounce back from last weekends 7-0 mauling at Brentford have not been helped by a growing injury list.
The Hatters host Wigan on Saturday but will be without Brendan Galloway and Izzy Brown for the Sky Bet Championship fixture.
On-loan Chelsea forward Brown suffered a hamstring tear at Brentford and is out for the foreseeable future, while Galloway ruptured his patella and is set for a long rehabilitation.
Both join Danny Hylton on the sidelines, although the experienced forward will return from a knee injury before the year is out.
Wigan are looking to respond after a disappointing defeat at home to Reading last time out and Paul Cook could make more changes.
Kieffer Moore and Jamal Lowe dropped to the bench for the clash with the Royals and this time he could turn to teenager Joe Gelhardt.
The Latics remain without Danny Fox (groin) until the new year while Joe Williams is still out with a hamstring injury.
Midfielder Lee Evans has not featured since the beginning of October due to a calf issue and remains unavailable.
Luton (21) v Wigan (22)
Last season: No corresponding fixture
Last five league matches: Luton L L L W L; Wigan L L L D L
Top scorers (all competitions): James Collins (Luton) 6; Cheyenne Dunkley (Wigan) 5
Luton Town v Wigan Athletic
The Hatters host Wigan on Saturday but will be without Brendan Galloway and Izzy Brown for the Sky Bet Championship fixture.
On-loan Chelsea forward Brown suffered a hamstring tear at Brentford and is out for the foreseeable future, while Galloway ruptured his patella and is set for a long rehabilitation.
Both join Danny Hylton on the sidelines, although the experienced forward will return from a knee injury before the year is out.
Wigan are looking to respond after a disappointing defeat at home to Reading last time out and Paul Cook could make more changes.
Kieffer Moore and Jamal Lowe dropped to the bench for the clash with the Royals and this time he could turn to teenager Joe Gelhardt.
The Latics remain without Danny Fox (groin) until the new year while Joe Williams is still out with a hamstring injury.
Midfielder Lee Evans has not featured since the beginning of October due to a calf issue and remains unavailable.
Luton (21) v Wigan (22)
Last season: No corresponding fixture
Last five league matches: Luton L L L W L; Wigan L L L D L
Top scorers (all competitions): James Collins (Luton) 6; Cheyenne Dunkley (Wigan) 5
Match odds: H 7-5 D 5-2 A 19-10
Referee: Andrew Madley (West Yorkshire)
Luton vs Wigan predictions
Luton 2-1 @ 17/2
Luton to Win @ 7/5
Head to Head Comparison
Luton Town - Last 5 Matches
Wigan Athletic - Last 5 Matches